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  • SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination…
  • Journal of Pathology, Microbiology and Immunology – the APMIS journal
  • Copenhagen University Hospital


  • Authors have no conflicts of interest to declare.
  • Denmark used Pfizer-BioNTech (BTN162b2) Moderna (mRNA-1273)
  • Both code for production of the full-length SARS-CoV-2 spike protein mRNA is encapsulated in lipid nanoparticles
  • Non replicating
  • The modified nucleotide sequences allow perfect identification of the vaccine sequences
  • Patients with chronic hepatitis C virus (HCV) infection Received mRNA vaccinations
  • To monitor HCV infection, RNA was extracted from patient plasma
  • In 10 of 108 HCV patient samples, full-length or traces of SARS-CoV-2 spike mRNA vaccine sequences were found in blood, up to 28 days after COVID-19 vaccination.

Professor Hoiby


  • Upon intramuscular injection, the vaccine mRNA is taken up by muscle and immune cells, and transported to the regional lymph nodes, and concentrated in the spleen
  • The vaccines consist of nonreplicating mRNA, expected to naturally decompose, both within the cytosol after translation and at the injection site.
  • Half-life of mRNA translation, estimated from hours to a day.
  • Translation is described to span up to 10 days
  • The Infectious Diseases Society of America (IDSA)…

  • Vaccine mRNA is degraded quickly, by normal intracellular processes, there is no evidence for long-term detection of mRNA vaccines
  • Method used in Denmark Genotyping whole RNA genome sequencing NCH and SARS-CoV-2 mRNA, directly from plasma samples
  • We describe the unexpected finding of SARS-CoV-2 vaccine mRNA sequences
  • Five consecutive sequencing runs (May 2021 to the end of June 2021)
  • Five negative controls and five HCV-positive controls


  • Both mRNA vaccine sequences have been modified and are only ~70% identical to the spike reference genome on a nucleotide level, making them distinct from circulating infectious SARS-CoV-2 sequences.
  • Of the 108 patient samples, 10 samples (9.3%) had partial or up to full sequences of the vaccine mRNA sequence


  • Analysis of mRNA vaccine function has focused on the immune response, and on protection of vaccinated individuals
  • The LNPs have been reported to be rapidly cleared by immune cells, and mRNA rapidly degraded
  • We expect that vaccine mRNA detected in plasma is contained within LNPs
  • To our knowledge, our study is the first to detect Pfizer-BioNTech and Moderna COVID-19 mRNA vaccine sequences in blood after vaccination, and therefore provides new knowledge regarding the timeframe in which the mRNA can be detected.
  • A future prospective study to establish the half-life of mRNA vaccines in vaccine recipients could be performed (using mRNA vaccine-specific PCRs)

Originally posted at Dr Campbells YouTube Channel


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