US says its climate financing reached $11 bn this year

President Joe Biden is using a historic trip to the Amazon on Sunday to highlight that US bilateral climate financing increased to $11 billion this year, meeting a pledge he made. “The fight against climate change has been a defining cause of President Biden’s leadership and presidency,” the White House said in a statement ahead […]

The post US says its climate financing reached $11 bn this year appeared first on Insider Paper.

Tropical Storm Sara Public Advisory Number 16

…SARA NOW JUST INLAND OVER BELIZE…
…HEAVY RAINFALL TO CONTINUE AS IT MOVES INLAND OVER PORTIONS OF
THE YUCATAN PENINSULA…
Location: 17.1°N 88.4°W
Max sustained: 40 mph
Moving: WNW at 6 mph
Min pressure: 1001 mb

Issued at 900 AM CST Sun Nov 17 2024

G7 Vows To Keep Imposing ‘Severe Costs’ On Russia As War Reaches 1,000 Days

G7 Vows To Keep Imposing ‘Severe Costs’ On Russia As War Reaches 1,000 Days

Leaders of the Group of Seven (G7) have issued a Saturday statement vowing to support Ukraine as long as it takes to defeat Russia, vowing to impose severe costs on Moscow, in line with prior Washington statements vowing to ‘weaken’ Russia.

This comes amid growing Western behind the scenes action to engage Putin on the diplomatic front, in response to President-elect Donald Trump preparing to enter the White House, where a top priority is to negotiate a swift end to the war in Ukraine. This coming Tuesday will mark 1,000 days since Russia’s full-scale invasion in February 2022.

“Russia remains the sole obstacle to just and lasting peace,” the new joint statement says. It pledges to support more measures “in support of Kyiv as the thousandth day of Russia’s war of aggression against Ukraine approaches.”

The group major industrial countries consists of the US, France, Canada, Germany, Italy, Japan, and the UK. Currently Italy holds to the rotating presidency.

“The G7 confirms its commitment to imposing severe costs on Russia through sanctions, export controls and other effective measures. We stand united with Ukraine,” the statement added.

The European Union is a ‘non-enumerated’ member of the G7. The European Commission’s chief Ursula von der Leyen issued a simultaneous statement on X saying the “G7 reiterates its unflinching support to Ukraine.”

“G7 partners stand with the brave Ukrainian nation,” von der Leyen concluded, at a moment there is widespread recognition that Russia is steadily advancing in the east, and will soon solidify control over the whole of the Donbass.

On the nuclear front, the Pentagon has issued a more measured and somewhat conciliatory statement in a report to Congress:

“The United States will abide by the central limits of the New START Treaty for the duration of the Treaty as long as it assesses that Russia continues to do so,” the Pentagon said in the report on the nuclear weapons employment strategy of the United States.

The US is also committed to future arms control with its nuclear-armed competitors, but any future accords will “need to account for US deterrence requirements and other strategic threats globally,” the report said.

Since Trump’s election the ratcheting nuclear rhetoric and warnings from the Russian side appear to have cooled. A key rationale of Trump’s team in making the case for a necessary and quick winding down of the war is that the West must avoid nuclear confrontation or a WW3 scenario with Russia at all costs.

War-weary populations across Europe and the West are also in favor of peace, all recent polling shows, and Trump has been given a clear mandate by US voters to seek a diplomatic end to the war.

President Zelensky has also admitted this past week that the war will likely end sooner under Trump. He is pressing for a “just peace” – but is unlikely to assent to anything without firm security guarantees from NATO countries. Still, Zelensky is warning allies not to appease Putin by hasty engagement on the diplomatic front. “What is needed are concrete, strong actions that will force him to peace, not persuasion and attempts at appeasement, which he sees as a sign of weakness and uses to his advantage,” a statement from Zelensky’s office said Friday.

Tyler Durden
Sun, 11/17/2024 – 07:35

Russia Signals Openness to Ukraine Peace Talks Under Trump, Says Must Reflect ‘Realities on the Ground’

from Your News: Moscow expresses readiness for negotiations to end the Ukraine conflict if U.S. President-elect Donald Trump initiates the process, but insists talks must reflect “realities on the ground.” By yourNEWS Media Newsroom In the wake of President-elect Donald Trump’s landslide victory, Moscow has indicated its willingness to engage in peace negotiations over the […]

Worm meds

Repositioning of Anthelmintic Drugs for the Treatment of Cancers of the Digestive System

https://pmc.ncbi.nlm.nih.gov/articles/PMC7404055/

Tumours of the digestive system,

their incidence continues to increase.

The process discovering and validating novel and effective drugs against these malignancies, lengthy and costly

Drug repositioning (drug repurposing), finding new uses for approved drugs,

provides the opportunity to expedite promising anti-cancer agents into clinical trials.

Some classes of anthelmintics

Infections caused by parasitic worms (helminths)

Meds have shown pronounced anti-tumor activities

Ability to target key oncogenic signal transduction pathways.

Benzimidazoles

Some have been successfully tested for the treatment of gastrointestinal, liver and pancreatic cancers.

Mebendazole

Blocks tubulin polymerization, compromise microtubule function

Seen to inhibit cell growth and invasion of ascites cell line derived from a primary gastric tumor,

whether used alone or in combination with chemotherapeutic

Treatment was also successfully tested in five CRC cell lines,

showed no cytotoxic activity against three cell lines with non-malignant phenotype

Induced remission of lung and lymph node metastases, and a partial remission of liver metastases, in a patient with refractory metastatic colon cancer

Showed anti-cancer properties in the treatment of hepatocellular carcinoma

Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers

https://pmc.ncbi.nlm.nih.gov/articles/PMC9862092/

Albendazole

Cytostatic effect on the human cancer cell lines

Potential anti-cancer agent also for the treatment of HCC

Pancreatic cancer lines

Positive mice studies, some early human studies

Ivermectin

CRC, gastric cancer

(vitro and in vivo)
Ivermectin, a potential anticancer drug derived from an antiparasitic drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/

Mechanisms of action

IVM induces different programmed cell death patterns, e.g. apoptosis.

Forms of cancer

Breast cancer

Digestive system cancer

Gastric cancer

Hepatocellular carcinoma

Urinary system cancer

Renal cell carcinoma

Prostate cancer

Hematological cancer

Leukemia

Reproductive system cancer

Cervical cancer

Ovarian cancer

Brain glioma

Glioblastoma

Respiratory system cancer

Nasopharyngeal carcinoma

Lung cancer

Melanoma

Right to Try

https://trumpwhitehouse.archives.gov/briefings-statements/president-donald-j-trump-sign-right-try-legislation-fulfilling-promise-made-expand-healthcare-options-terminal-americans/

Kathleen T Ruddy, MD

https://twitter.com/DocRuddy

Trump and team get warm welcome at UFC fight night

US President-elect Donald Trump was greeted by chanting fans as he attended the Ultimate Fighting Championship heavyweight bout at New York’s Madison Square Garden on Saturday. Trump entered the arena shortly before the start of the main card accompanied by UFC chief executive Dana White, who was a prominent backer during his election campaign. Several […]

The post Trump and team get warm welcome at UFC fight night appeared first on Insider Paper.

Tropical Storm Sara Public Advisory Number 15A

…SARA NEARING LANDFALL ALONG THE BELIZE COAST WITH HEAVY RAINS
MOVING INLAND OVER PORTIONS OF THE YUCATAN PENINSULA…
Location: 16.7°N 87.9°W
Max sustained: 40 mph
Moving: WNW at 5 mph
Min pressure: 1002 mb

Issued at 600 AM CST Sun Nov 17 2024

Tropical Storm Sara Public Advisory Number 15

…HEAVY RAINS SPREADING INLAND OVER PORTIONS OF BELIZE AND THE
YUCATAN PENINSULA…
Location: 16.8°N 87.8°W
Max sustained: 40 mph
Moving: WNW at 5 mph
Min pressure: 1002 mb

Issued at 300 AM CST Sun Nov 17 2024

Tropical Storm Sara Forecast Advisory Number 15

Issued at 0900 UTC SUN NOV 17 2024