• John Campbell
• News , Politics , Science
• October 26, 2024
• 18 views

Common mucosal system and immunity

Professor Robert Clancy announces some of his new research findings. The microbiome and using bacteria based preparations to impressive theraputic effect, often without expensive drugs.
https://www.trialsitenews.com/a/a-common-mucosal-protection-system-inclusive-of-microbiomes-and-local-immunity-cognisance-through-covid-fe9bbf21

The Covid pandemic drew attention to the distinctive system of mucosal immunity and its limited interplay with systemic immunity with which we were more familiar. The pandemic coincided with a period of fifty years from the recognition of a communicating mucosal immune system. John Bienenstock called this “The Common Mucosal Immune System” (CMS). Lessons relevant to Covid on the relevance of mucosal immunity to both the pathogenesis of disease and vaccination strategies were slowly learnt. Early in the pandemic, protracted changes in the intestinal microbiota were noted that correlated with the progress and severity of infection, and later were linked to development of post-Covid syndrome. The purpose of this review is to pull together through the lens of Covid-19 how a viral infection of the respiratory mucosal space connects with systemic immunity on one hand, and mucosa-related microbiota on the other, within a single integrated mucosal system, to create a carpet of protection. Infection within this unified system can induce changes in balance between microbiota and the relevant local immune response at distant mucosal sites, which in turn, can impact the outcome of the inciting infection in either a deleterious or beneficial manner. Within the broader framework that includes systemic immunity, outcomes of both infection and vaccination, reflect a controlled balance determined by downregulation via suppressor T cells seeded from mucosal sites of infection. The integrity of this comprehensive system has been queried based on regional differences. Such a view fails to recognise mechanisms of critical outcomes of Covid and its management, and opportunities for innovative therapeutic intervention. Variations throughout the mucosal apparatus such as “offsite” generation of airway immunity in the gut and differences in microbial characteristics of microbiomes, reflect adaptation to local influences without compromising the essential qualities of a global mucosal protection system: communication, integration, and cooperation. A central unifying factor for a “Mucosal Immune Microbiome Protection System” or MIMPS, is the idea that a single set of gut-associated lymphoid tissues characterised by specialised M cells, samples appropriate microbiome to generate global mucosal immune defence.

• John Campbell
• News , Politics , Science
• October 25, 2024
• 18 views

New mRNA vaccine trials

Intradermal Mycobacterium vaccae and obuense (IMM-101)

Oral Non-typeable Haemophilus influenzae (NTHi)

UK could be first country to offer norovirus jab against ‘winter vomiting bug’

New vaccine could stop people developing the highly infectious illness after early trial results found it creates a ‘strong immune response’

https://www.telegraph.co.uk/news/2024/10/23/norovirus-vaccine-winter-vomiting-bug-moderna-wes-streeting/

mRNA

Systemic distribution inevitable

Antigenic dose produced varies

Longevity of mRNA?

Use of synthetic base

Contamination from manufacturing process

https://www.nihr.ac.uk/news/uks-first-norovirus-mrna-vaccine-trial-launched

First Phase 3 randomised clinical trial

Nova 301 trial, mRNA-1403

Trivalent, targeting three major strains of norovirus

mRNA norovirus vaccine, UK wide, 39 sites

Sponsored by Moderna,

Trial evaluates the efficacy and safety of mRNA-1403

Aims to recruit 2,500 participants, UK, late October to early 2025

Some mobile sites for community visits

25,000 globally

Half mRNA, half placebo

18 years + but 60 + wanted
Single dose vaccine at the first visit – a jab given in the upper arm.

The trial lasts up to 25 months.

At least six in-person visits to the clinical trial site,

and five phone calls with the trial team.

Part of a 10-year partnership between Moderna and the UK Health Security Agency (UKHSA) on behalf of UK Government

https://www.gov.uk/government/news/uk-cements-10-year-partnership-with-moderna-in-major-boost-for-vaccines-and-research

UK Vaccine Innovation Pathway (VIP) and the NIHR working together to accelerate vaccine trials in the UK.

https://bepartofresearch.nihr.ac.uk/?utm_source=nihr-website&utm_medium=referral&utm_campaign=bpor-nova

Dr Patrick Moore, Chief Investigator of the trial

The UK is really pleased to be able to play an important role in helping find an effective vaccine against this highly contagious disease.
NIHR Chief Executive Professor Lucy Chappell

Leveraging the UK’s expertise in vaccine development, the DHSC through the NIHR and Moderna are delivering this large-scale trial at pace,

so that people across the UK and the world can benefit sooner.

From the NIHR site

the Nova 301 trial serves as a model for future collaborations between the public and private sectors in advancing medical research.

Norovirus

https://www.cdc.gov/norovirus/data-research/index.html#:~:text=Economic%20impact,-Norovirus%20illness%20is&text=Every%20year%2C%20norovirus%20is%20estimated,healthcare%20costs%20and%20lost%20productivity.

https://emedicine.medscape.com/article/224225-overview

Worldwide, about 1 out of every 5 cases of acute gastroenteritis is caused by norovirus.

Gastroenteritis typically develops 12-48 hours after ingestion of contaminated food or water or after contact with an infected individual.

Symptoms typically last for 24-72 hours.

All ages

Nausea and vomiting

Watery diarrhea

Possible dehydration

Abdominal cramps

Headaches

Low-grade fever

Myalgias and malaise

Norovirus genus

More than 40 different strains

GII.4 Sydney

Transmission

Person to person, direct contact, exposure to aerosols, fecal–oral routes.

ID50 = 10 virions

• John Campbell
• News , Politics , Science
• October 25, 2024
• 18 views

Professor Angus Dalgleish, full interview

World class discussion for the serious viewer. Professor Dalgleish informs us about several important topics: Problems encountered on his tour of Australia. Lessons learned from his research into cancer vaccines. The potential for ivermectin aid in cancer treatment. Vitamin D is essential in cancer treatment. Obvious mistakes in production of Covid vaccines. Evidence from virology for a lab leak of the covid virus. The existence of a simple bacterial preparation to treat sever cancers and infections which has been refused regulator approval.

• John Campbell
• News , Politics , Science
• October 24, 2024
• 17 views

Viral origins evidence

• John Campbell
• News , Politics , Science
• October 23, 2024
• 19 views

New Vitamin D paper

Vitamin D: A key player in COVID‐19 immunity and lessons from the pandemic to combat immune‐evasive variants

https://link.springer.com/article/10.1007/s10787-024-01578-w

As of July 2024

775,754,322 confirmed cases of COVID-19

13,578,710,228 vaccine doses had been administered

It is unclear why some patients develop severe symptoms while others do not,

literature suggests a role for vitamin D.

Vitamin D plays a crucial role in the infection or in ameliorating the severity of symptoms.

VDD is associated with increased hospitalization of severely ill patients and increased levels of COVID-19-caused mortality.

The mechanism of action of vitamin D and vitamin D deficiency (VDD) is well understood.

Vitamin D levels and genetic variations in the vitamin D receptor (VDR) gene significantly impact the severity and out- comes of COVID-19,

especially in the infections caused by Delta and Omicron variants.

Furthermore, VDD causes immune system dysregulation upon infection with SARS-CoV-2,

indicating that vitamin D sufficiency is crucial in fighting against COVID-19 infection.

Potential role as a prophylactic and treatment adjunct.

Immunomodulatory and anti-inflammatory effects of vitamin D

Ability to enhance the efficacy of new antiviral drugs

Large- scale randomized trials are required to reach a definitive conclusion.

Mechanisms of action

Macrophages activated to produce defensive proteins and stimulate naïve T cells

Activate T lymphocytes and mature B lymphocytes into plasma cells

Prevents inflammation, vasoconstriction, and fibrosis of the lungs.

Prevents excess release of cytokines from macrophages

Prevents excessive CRP production in the liver

Vit D can reduce viral replication

Vitamin D can protect against ARDS, the main death-causing complication of COVID-19

Seven out of nine studies reviewed by Yisak

https://pubmed.ncbi.nlm.nih.gov/33447107/

have indicated a crucial role in vitamin D status in COVID-19 infection, prognosis, and mortality.

Vitamin D dose

To decrease the risk of contracting a new infection,

people at high risk of COVID-19 to take 10,000 IU d−1 of vitamin D for a few weeks,

followed by 5000 IU d−1 to raise the concentrations of the active form of vitamin D.

Blood levels

Levels below 12 ng/mL indicate severe deficiency.

Levels between 12 and 20 ng/mL suggest deficiency

Treatment recommended for levels below 30 ng/mL

Optimal levels are 30–60 ng/mL,

Recommended prophylactic dose

0–1 years, 400 IU/day (10 mcg)

over  1 year, 600 IU (15 mcg)

over 8 years, half an adult dose

Adults, 800– 2000 IU of cholecalciferol

Routine toxicity monitoring is unnecessary for doses under 10,000 IU/day

• John Campbell
• News , Politics , Science
• October 21, 2024
• 24 views

Governmrnt prevents me getting vaccinated

Introduction to the lectures given in Australia with Professor Angus Dalgleish.

• John Campbell
• News , Politics , Science
• October 20, 2024
• 14 views

Cancers

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/

Mechanisms of action

IVM induces different programmed cell death patterns in different tumor cells,

the main form of IVM induced programmed cell death is apoptosis.

Apoptosis

Programmed cell death

Autophagy

Lysosomal-dependent form of programmed cell death.

Pyroptosis

Inflammatory cell death induced by inflammasomes.

Kathleen T Ruddy, MD

https://twitter.com/bobanderson77/status/1797002359521866017/video/1

https://rumble.com/v4vk4pw-oncologist-kathleen-rudy-reveals-horse-dewormer-aka-ivermectin-cure-cancer.html

https://twitter.com/DocRuddy

https://rumble.com/v4vk4pw-oncologist-kathleen-rudy-reveals-horse-dewormer-aka-ivermectin-cure-cancer.html

Forms of cancer

Breast cancer

A malignant tumor produced by gene mutation in breast epithelial cells

Digestive system cancer

Gastric cancer is one of the most common malignant tumors worldwide.

Hepatocellular carcinoma is the fourth leading cause of cancer death worldwide.

Urinary system cancer

Renal cell carcinoma is a fatal malignant tumor of the urinary system derived from renal tubular epithelial cells.

Prostate cancer is a malignant tumor derived from prostate epithelial cells

Hematological cancer

Leukemia is a type of malignant clonal disease caused by abnormal hematopoietic stem cells

Reproductive system cancer

Cervical cancer is one of the most common gynecological malignancies

Ovarian cancer is a malignant cancer that lacks early clinical symptoms and has a poor therapeutic response.

Brain glioma

Glioma is the most common cerebral tumor

Glioblastoma, median survival time of 14-17 months

Respiratory system cancer

Nasopharyngeal carcinoma is a malignant tumor derived from epithelial cells of the nasopharyngeal mucosa.

Lung cancer has the highest morbidity and mortality among cancers

Melanoma

The most common malignant skin tumor with a high mortality rate.

Other papers

Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205794/

Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug

https://pubmed.ncbi.nlm.nih.gov/32474842/

Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer

https://www.nature.com/articles/s41523-021-00229-5

Abstract 2320: Ivermectin suppresses pancreatic cancer via mitochondria dysfunction

https://aacrjournals.org/cancerres/article/82/12_Supplement/2320/701043/Abstract-2320-Ivermectin-suppresses-pancreatic

Video reviews

https://www.youtube.com/watch?v=vCgNaOvICsk

https://www.youtube.com/@dr.kathleenruddy1734/videos

https://www.youtube.com/watch?v=m_78xfHRHUY

https://www.youtube.com/watch?v=jaY2BeNnfy8

• John Campbell
• News , Politics , Science
• October 18, 2024
• 12 views

Proof, DNA contamination report

Summary of my interview with analytical virologist Dr. David J. Speicher,
Substack: https://drdavidjspeicher.substack.com/

GiveSendGo: https://drdavidjspeicher.substack.com/p/launching-my-give-send-go-campaign

Kevin’s Substack: https://anandamide.substack.com/p/vaccine-targeted-qpcr-of-cancer-cell?utm_source=profile&utm_medium=reader2

Report from Canadian virologist, Dr. David Speicher

https://www.dropbox.com/scl/fi/sb20elb520v6a1saxg9lj/240909-D-Speicher-Report.pdf?rlkey=dutcvd85gh80ebfs2ucdmorba&e=3&st=0jpsw84f&dl=0

Maria Gutschi: https://mariagutschi.substack.com/

• John Campbell
• News , Politics , Science
• October 17, 2024
• 14 views

I see my cardiologist

Link for the full film First do no Pharm, https://cerealkillers.gumroad.com/l/nopharmfilm/drjohn

This is film isn't just an exposé – it's a call to arms. It will provide you with the knowledge and tools to fight back against a system that values profits over patients. We'll show you how to navigate this treacherous landscape, how to protect yourself and your loved ones from the excesses of an industry gone mad.

Email for Dr. Malhotra consultations
concierge@hum2n.com