Kamala Harris Admits She’s ‘Not Perfect’ but Would Not Admit a Mistake

Vice President Kamala Harris acknowledged during a Wednesday CNN town hall that she is “not perfect,” although she would not admit to making a mistake on any specific policy.

The post Kamala Harris Admits She Is ‘Not Perfect’ but Will Not Admit a Mistake on Anything appeared first on Breitbart.

Hurricane Kristy Forecast Advisory

Issued at 0300 UTC THU OCT 24 2024

Hurricane Kristy Public Advisory

…KRISTY REMAINS A VERY POWERFUL CATEGORY 4 HURRICANE…
As of 8:00 PM PDT Wed Oct 23
the center of Kristy was located near 14.2, -117.2
with movement W at 20 mph.
The minimum central pressure was 928 mb
with maximum sustained winds of about 155 mph.

Harris Closing Argument Ignores Issues Facing Americans, Calls Trump ‘Fascist’

Former President Donald Trump is a “fascist,” Vice President Kamala Harris claimed for the first time during a Wednesday CNN town hall.

The post Kamala Harris Closing Argument Ignores Issues that Face Americans: She Calls Donald Trump a ‘Fascist’ appeared first on Breitbart.

Saudi Arabia, Iran in Sea of Oman war games: spokesman

Saudi Arabia held military exercises with Iran and other countries recently in the Sea of Oman, the Saudi defence ministry spokesman said in a statement to AFP Wednesday. The two Middle East rivals, which have long backed opposing sides in conflict zones across the region, severed diplomatic ties in 2016. However Shiite Muslim-dominated Iran and […]

The post Saudi Arabia, Iran in Sea of Oman war games: spokesman appeared first on Insider Paper.

Apple “Might Wind Down” Vision Pro Production Next Month Due To “Weak Demand” 

Apple “Might Wind Down” Vision Pro Production Next Month Due To “Weak Demand” 

A new report from The Information suggests Apple might suspend production of its Vision Pro mixed-reality headset as early as next month due to very weak demand. Some Asian suppliers have already reduced or stopped producing headset components since the summer. Additionally, the development of the next Vision Pro model has been delayed, while a more affordable headset is slated for the retail market by the end of 2025. 

The first version has met weak demand, a result of its high price and the lack of apps available on it. Employees at three Vision Pro suppliers that supply a range of electrical and mechanical components told The Information they have so far built enough components for between 500,000 and 600,000 headsets.

One of the employees said their factory suspended production of Vision Pro components in May based on Apple’s weak forecasts, and their warehouse remains filled with tens of thousands of undelivered parts.

. . . 

In recent weeks, Apple has told Luxshare, which is responsible for the Vision Pro’s final assembly, that it might need to wind down its manufacturing in November, according to an employee at the Chinese manufacturer. Luxshare is making around 1,000 Vision Pro units a day, down from a peak of around 2,000 units a day, the employee said. It has assembled a total of between 500,000 and 600,000 headsets since production began last year ahead of its February release in the U.S., the employee said.

Apple’s move into the mixed-reality headset market with its $3,500 Vision Pro seems poorly timed, given the financial strain on many low- to mid-tier consumers. High inflation and elevated interest rates, primarily attributed to failed Bidenomics, have left millions of cash-strapped Americans in financial misery as they struggle to cover basic expenses like rent, groceries, car payments, insurance, and phone bills.

The Vision Pro flop is nothing new to readers. We commented on a WSJ note earlier this month that showed the dismal demand for the headset means no ‘killer app’ anytime soon:

There has been a significant slowdown in new apps coming to the Vision Pro every month. Only 10 apps were introduced to the Vision App Store in September, down from the hundreds released in the first two months of the device’s launch, according to analytics firm Appfigures.

It has counted around 1,770 apps available for the Vision Pro in the App Store as of September. Only 34% of those apps are built specifically for the Vision Pro, while the rest are versions of existing Apple apps that have additional Vision Pro functionality, Appfigures said.

Apple said in August that there are more than 2,500 apps built for the Vision Pro. Appfigures said the discrepancy between these two figures could be, in part, because some apps aren’t used enough to register on usage charts, making them difficult for the analytics firm to detect.

A visualization from WSJ shows a considerable decline in the number of new apps released for Vision Pro every month since its launch.

Source: WSJ

We’ve previously noted…

Even from the start. 

Just like the AI-enabled iPhone 16, another bust for Apple. 

Tyler Durden
Wed, 10/23/2024 – 18:00

Hurricane Kristy Public Advisory

…KRISTY CONTINUES TO RAPIDLY INTENSIFY…
As of 2:00 PM PDT Wed Oct 23
the center of Kristy was located near 14.1, -115.5
with movement W at 20 mph.
The minimum central pressure was 928 mb
with maximum sustained winds of about 155 mph.

Hurricane Kristy Forecast Advisory

Issued at 2100 UTC WED OCT 23 2024

New Vitamin D paper

Vitamin D: A key player in COVID‐19 immunity and lessons from the pandemic to combat immune‐evasive variants

https://link.springer.com/article/10.1007/s10787-024-01578-w

As of July 2024

775,754,322 confirmed cases of COVID-19

13,578,710,228 vaccine doses had been administered

It is unclear why some patients develop severe symptoms while others do not,

literature suggests a role for vitamin D.

Vitamin D plays a crucial role in the infection or in ameliorating the severity of symptoms.

VDD is associated with increased hospitalization of severely ill patients and increased levels of COVID-19-caused mortality.

The mechanism of action of vitamin D and vitamin D deficiency (VDD) is well understood.

Vitamin D levels and genetic variations in the vitamin D receptor (VDR) gene significantly impact the severity and out- comes of COVID-19,

especially in the infections caused by Delta and Omicron variants.

Furthermore, VDD causes immune system dysregulation upon infection with SARS-CoV-2,

indicating that vitamin D sufficiency is crucial in fighting against COVID-19 infection.

Potential role as a prophylactic and treatment adjunct.

Immunomodulatory and anti-inflammatory effects of vitamin D

Ability to enhance the efficacy of new antiviral drugs

Large- scale randomized trials are required to reach a definitive conclusion.

Mechanisms of action

Macrophages activated to produce defensive proteins and stimulate naïve T cells

Activate T lymphocytes and mature B lymphocytes into plasma cells

Prevents inflammation, vasoconstriction, and fibrosis of the lungs.

Prevents excess release of cytokines from macrophages

Prevents excessive CRP production in the liver

Vit D can reduce viral replication

Vitamin D can protect against ARDS, the main death-causing complication of COVID-19

Seven out of nine studies reviewed by Yisak

https://pubmed.ncbi.nlm.nih.gov/33447107/

have indicated a crucial role in vitamin D status in COVID-19 infection, prognosis, and mortality.

Vitamin D dose

To decrease the risk of contracting a new infection,

people at high risk of COVID-19 to take 10,000 IU d−1 of vitamin D for a few weeks,

followed by 5000 IU d−1 to raise the concentrations of the active form of vitamin D.

Blood levels

Levels below 12 ng/mL indicate severe deficiency.

Levels between 12 and 20 ng/mL suggest deficiency

Treatment recommended for levels below 30 ng/mL

Optimal levels are 30–60 ng/mL,

Recommended prophylactic dose

0–1 years, 400 IU/day (10 mcg)

over  1 year, 600 IU (15 mcg)

over 8 years, half an adult dose

Adults, 800– 2000 IU of cholecalciferol

Routine toxicity monitoring is unnecessary for doses under 10,000 IU/day